Arranging your plots will influence how long it takes for you to plant, water, and harvest the plats. The faster you complete this, the more time you can take to earn experience and find samples in the wild!
When you first start building your plot design, you want to move your well closer. You can do this by entering "Planning Mode" and clicking on the well, you will then be able to move and rotate it. By placing it in the middle of an open space, you can buildplots around it. Making it very easy to access water from the well and water plants.
The closer your plants are to the shed and well, the better. Like the watering well, you can also move your tool shed closer to where your plots are located. That way you do not have to run far to pick up your fungus killer, watering can, bug sprayer, etc.